Immunology Quiz

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1 / 20

The absence of which molecule would most impair the presentation of endogenous antigens to CD8+ T cells?

MHC Class II

TAP1/TAP2

CD28

CD40

2 / 20

Hypersensitivity reactions are classified into how many types?

3 / 20

Which transcription factor is crucial for regulatory T cell (Treg) development?

RORγt

GATA-3

T-bet

Foxp3

4 / 20

Which molecule is critical for the migration of dendritic cells from peripheral tissues to lymph nodes?

IL-12

CD80

CD40

CCR7

5 / 20

What is the function of CTLA-4 on T cells?

Promotes proliferation

Enhances T cell survival

Competes with CD28 to inhibit costimulatory signaling

Increases cytokine production

6 / 20

Which cytokine is mainly involved in the induction of fever?

IL-10

IL-6

IL-1

TNF-α

7 / 20

Which MHC molecule presents endogenous (intracellular) antigens to CD8+ T cells?

MHC Class III

MHC Class II

MHC DQ

MHC Class I

8 / 20

Which subclass of IgG has the highest affinity for FcγRI (CD64) receptors?

IgG3

IgG4

IgG2

IgG1

9 / 20

Which of the following cells are antigen-presenting cells (APCs)?

B cells

Dendritic cells

All of the above

T helper cells

10 / 20

Which cytokine is primarily responsible for promoting isotype switching to IgE?

IFN-γ

IL-10

IL-2

IL-4

11 / 20

Activation-Induced Cytidine Deaminase (AID) is required for which immunological process?

MHC class II antigen loading

Complement activation

Somatic hypermutation and class switch recombination

T cell receptor rearrangement

12 / 20

Somatic hypermutation occurs in which part of the immune system?

Thymus

Bone marrow

Germinal centers of lymph nodes

Liver

13 / 20

Anergy in T cells is primarily caused by:

Presence of superantigens

Excessive IL-2 production

Antigen recognition without co-stimulatory signals

Absence of antigen presentation

14 / 20

Which cytokine is mainly responsible for the proliferation of hematopoietic stem cells in the bone marrow?

IL-1

TNF-α

IL-7

IL-3

15 / 20

The main function of the invariant chain (Ii) in MHC Class II antigen processing is to:

Block the peptide-binding groove of MHC II in the ER

Degrade antigens in endosomes

Help export peptides out of the ER

Facilitate antigen loading onto MHC I

16 / 20

The process of class switch recombination in B cells requires the presence of which molecule?

IL-1

RAG1/2

TdT

Activation-Induced Cytidine Deaminase (AID)

17 / 20

Hypersensitivity reactions are classified into how many types?

18 / 20

Which of the following is a primary lymphoid organ?

Tonsils

Spleen

Thymus

Lymph node

19 / 20

Which cell is responsible for producing antibodies?

B cells

Neutrophils

Macrophages

T cells

20 / 20

Which of the following transcription factors is critical for the differentiation of Th1 cells?

FoxP3

GATA3

RORγt

T-bet

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