Immunology Quiz

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1 / 20

Which of the following cells are antigen-presenting cells (APCs)?

B cells

All of the above

Dendritic cells

T helper cells

2 / 20

Which MHC molecule presents endogenous (intracellular) antigens to CD8+ T cells?

MHC Class II

MHC Class III

MHC Class I

MHC DQ

3 / 20

Hypersensitivity reactions are classified into how many types?

4 / 20

Which enzyme complex is responsible for recombination of V(D)J gene segments in lymphocytes?

RAG1/RAG2

RNA polymerase

Cas9

AID

5 / 20

Which cell is responsible for producing antibodies?

Neutrophils

B cells

Macrophages

T cells

6 / 20

Which cytokine is primarily responsible for promoting isotype switching to IgE?

IFN-γ

IL-10

IL-4

IL-2

7 / 20

The function of the immunological synapse formed between a T cell and an antigen-presenting cell includes:

Facilitation of TCR signaling and directed secretion

Inhibition of antigen processing

Suppression of cytokine release

Blocking costimulatory signaling

8 / 20

Hypersensitivity reactions are classified into how many types?

9 / 20

The major histocompatibility complex (MHC) in humans is also known as:

MALT

CD8

TCR

HLA

10 / 20

Which of the following immunoglobulin isotypes is most effective at activating the classical complement pathway?

IgG4

IgM

IgA

IgE

11 / 20

Which cytokine is mainly involved in the induction of fever?

TNF-α

IL-10

IL-1

IL-6

12 / 20

The absence of which molecule would most impair the presentation of endogenous antigens to CD8+ T cells?

CD40

CD28

TAP1/TAP2

MHC Class II

13 / 20

The main function of the invariant chain (Ii) in MHC Class II antigen processing is to:

Degrade antigens in endosomes

Block the peptide-binding groove of MHC II in the ER

Help export peptides out of the ER

Facilitate antigen loading onto MHC I

14 / 20

Anergy in T cells is primarily caused by:

Absence of antigen presentation

Excessive IL-2 production

Presence of superantigens

Antigen recognition without co-stimulatory signals

15 / 20

Which complement component is responsible for the membrane attack complex (MAC) formation?

C1q

C5b

C3b

C4a

16 / 20

What is the function of CTLA-4 on T cells?

Competes with CD28 to inhibit costimulatory signaling

Enhances T cell survival

Promotes proliferation

Increases cytokine production

17 / 20

Which subclass of IgG has the highest affinity for FcγRI (CD64) receptors?

IgG1

IgG2

IgG3

IgG4

18 / 20

Which of the following is a primary lymphoid organ?

Tonsils

Spleen

Thymus

Lymph node

19 / 20

Which class of immunoglobulin is the first to appear in response to an antigen?

IgA

IgG

IgM

IgE

20 / 20

Which immunoglobulin is found in secretions like saliva and tears?

IgA

IgG

IgE

IgD

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