Immunology Quiz

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1 / 20

Hypersensitivity reactions are classified into how many types?

2 / 20

Which subclass of IgG has the highest affinity for FcγRI (CD64) receptors?

IgG4

IgG1

IgG2

IgG3

3 / 20

The function of the immunological synapse formed between a T cell and an antigen-presenting cell includes:

Blocking costimulatory signaling

Facilitation of TCR signaling and directed secretion

Inhibition of antigen processing

Suppression of cytokine release

4 / 20

Which cell is responsible for producing antibodies?

B cells

Macrophages

Neutrophils

T cells

5 / 20

Which molecule is critical for the migration of dendritic cells from peripheral tissues to lymph nodes?

CCR7

CD40

CD80

IL-12

6 / 20

Which cytokine is mainly involved in the induction of fever?

IL-10

IL-6

TNF-α

IL-1

7 / 20

Which complement component is responsible for the membrane attack complex (MAC) formation?

C5b

C3b

C4a

C1q

8 / 20

Which cytokine is primarily responsible for promoting isotype switching to IgE?

IL-4

IL-2

IFN-γ

IL-10

9 / 20

Somatic hypermutation occurs in which part of the immune system?

Germinal centers of lymph nodes

Thymus

Liver

Bone marrow

10 / 20

Which transcription factor is crucial for regulatory T cell (Treg) development?

RORγt

Foxp3

GATA-3

T-bet

11 / 20

Anergy in T cells is primarily caused by:

Antigen recognition without co-stimulatory signals

Absence of antigen presentation

Presence of superantigens

Excessive IL-2 production

12 / 20

Passive immunity is best exemplified by:

Maternal antibodies to the baby

Infection recovery

T-cell activation

Vaccination

13 / 20

Which of the following cells are antigen-presenting cells (APCs)?

Dendritic cells

T helper cells

B cells

All of the above

14 / 20

Hypersensitivity reactions are classified into how many types?

15 / 20

Which cytokine is mainly responsible for the proliferation of hematopoietic stem cells in the bone marrow?

IL-7

IL-3

IL-1

TNF-α

16 / 20

What is the function of CTLA-4 on T cells?

Enhances T cell survival

Competes with CD28 to inhibit costimulatory signaling

Promotes proliferation

Increases cytokine production

17 / 20

Which of the following transcription factors is critical for the differentiation of Th1 cells?

GATA3

FoxP3

RORγt

T-bet

18 / 20

Which class of immunoglobulin is the first to appear in response to an antigen?

IgM

IgE

IgG

IgA

19 / 20

Which MHC molecule presents endogenous (intracellular) antigens to CD8+ T cells?

MHC Class III

MHC DQ

MHC Class I

MHC Class II

20 / 20

The main function of the invariant chain (Ii) in MHC Class II antigen processing is to:

Degrade antigens in endosomes

Block the peptide-binding groove of MHC II in the ER

Facilitate antigen loading onto MHC I

Help export peptides out of the ER

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